Bim Williams
Consultant Gynaecologist
13th October 2015
❑ Definition
❑ Causes
❑ Investigation
❑ Treatment
❑ When to refer
❑ Case Studies
❑ Most menstrual cycles 22 – 35 days
❑ Normal menstrual flow 3 – 7 days
❑ Menstrual flow < 80ml
❑ Heavy menstrual bleeding (HMB)
❑ Inter – menstrual bleeding (IMB)
❑ Post – coital bleeding (PCB)
❑ Erratic / Irregular cycles
❑ Post-menopausal bleeding (PMB)
❑ Excessive menstrual blood loss which interferes with a woman’s physical, social, emotional and / or material quality of life
❑ Can occur alone or in combination with other symptoms
❑ Major impact on a woman’s quality of life
❑ Blood loss is subjective
❑ 30% women consider their bleeding excessive
❑ 1 in 20 GP visits in women aged 30-49
❑ 12% of Gynaecology referrals (80,000 per year)
❑ 30,000 treatments carried out per year
❑ P – Polyp
❑ A – Adenomyosis
❑ L – Leiomyoma
❑ M – & Hyperplasia
❑ C – Coagulopathy
❑ O – Ovulatory Dysfunction
❑ E – Endometrial Causes
❑ I – Iatrogenic
❑ N – Non classified
M.G. Munro, H.O. Critchley, M.S. Broder, I.S. Fraser
The FIGO classification system (“PALM-COEIN”) for causes of abnormal uterine bleeding in non-gravid women in the reproductive years, including guidelines for clinical investigation
Int J Gynaecol Obstet, 113 (2011), pp. 3–13
❑ Determine nature of the bleeding
❑ Duration of bleeding
❑ Related symptoms
❑ Impact on quality of life
❑ Other factors-comorbidity
❑ Physical Examination
❑ Abdominal & Pelvic Exam
❑ FBC
❑ Clotting Screen**rule out coagulation disorders e.g. (von Willebrand disease) if having HMB since her period started or family history of coagulation disorders
❑ Pelvic Ultrasound Scan**
❑ Hysteroscopy – if history suggests submucosal fibroids, polyps and endometrial pathology
❑ Tranexamic acid
❑ 1g three to four times daily for 3-4 days during her period
❑ From onset of heavy bleeding
❑ Stop after 3 cycles if no improvement
❑ NSAID’S – Mefenamic acid
❑ 500mg three times daily during heavy bleeding
❑ Relieves dysmenorrhea
❑ Stop after 3 cycles if no improvement
❑ Combined Oral Contraceptive Pill
❑ Oral Progesterone – Cyclical day 5-26 of cycle
❑ Injectable Progesterone-MPA
❑ Levenogesterol Intrauterine System
❑ Esmya – check European Medicine Agency review on Esmya inculding full safety measures and performing liver function test prior to and during use of Esmya for treatment of HMB due to fibroid